Development and Validation of a Prognostic Model for Post-Operative Recurrence of Pituitary Adenomas.

ABSTRACT:

Background

We aimed to assess clinical factors associated with tumor recurrence and build a nomogram based on identified risk factors to predict postoperative recurrence in patients with pituitary adenomas (PAs) who underwent gross-total resection (GTR).

Methods

A total of 829 patients with PAs who achieved GTR at Tongji Hospital between January 2013 and December 2018 were included in this retrospective study. The median follow-up time was 66.7 months (range: 15.6-106.3 months). Patients were randomly divided into training (n = 553) or validation (n = 276) cohorts. A range of clinical characteristics, radiological findings, and laboratory data were collected. Uni- and multivariate Cox regression analyses were applied to determine the potential risk factors for PA recurrence.

SUBMITTER: Lu L 

PROVIDER: S-EPMC9096140 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature