Association between the genetic variants of base excision repair pathway genes and allergic rhinitis susceptibility in Chinese children.

ABSTRACT:

Background

Allergic rhinitis (AR) is a frequent inflammatory disorder of the upper respiratory tract, which has complex patterns of inheritance. Accumulating evidence has shown the key roles of DNA damage in inflammatory diseases, and the base excision repair (BER) is the primary pathway responsible for DNA repair during inflammation.

Methods

Here, we performed a case-control study to investigate the associations between 20 potentially functional single nucleotide polymorphisms (SNPs) in 6 BER pathway genes (PARP1, hOGG1, FEN1, APEX1, LIG3, and XRCC1) and AR susceptibility in 508 AR cases and 526 controls which originated in China. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for evaluating the association

SUBMITTER: Liu W 

PROVIDER: S-EPMC9096143 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature