Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.

ABSTRACT: Despite repeated associations between T cell infiltration and outcome, human ovarian cancer remains poorly responsive to immunotherapy. We report that the hallmarks of tumor recognition in ovarian cancer-infiltrating T cells are primarily restricted to tissue-resident memory (TRM) cells. Single-cell RNA/TCR/ATAC sequencing of 83,454 CD3⁺CD8⁺CD103⁺CD69⁺ TRM cells and immunohistochemistry of 122 high-grade serous ovarian cancers shows that only progenitor (TCF1^low) tissue-resident T cells (TRM_stem cells), but not recirculating TCF1⁺ T cells, predict ovarian cancer outcome. TRM_stem cells arise from transitional recirculating T cells, which depends on antigen affinity/persistence, resulting in oligoclonal,

SUBMITTER: Anadon CM 

PROVIDER: S-EPMC9096229 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature