MiR-223-3p affects myocardial inflammation and apoptosis following myocardial infarction via targeting FBXW7.

ABSTRACT:

Background

Myocardial infarction (MI) is one of the main causes of disability and death in the world, leading to myocarditis and cardiomyocyte apoptosis. Studies have shown that microRNA (miRNA) is involved in myocarditis and apoptosis. The main purpose of this study was to explore the regulatory mechanism of miR-223-3p on myocarditis and apoptosis after MI.

Methods

We cultured H9c2 cells and detected the expression of miR-223-3p in cells treated with different concentrations of H₂O₂. Sprague Dawley (SD) rats were fed with normal diet, constructed an MI model and detect the expression of miR-223-3p in heart tissue. Overexpression or inhibition of miR-223-3p was conducted in MI model cells in vitro, and the contents of the inflammatory factors tum

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9096303 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature