Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology.

ABSTRACT: Cells are continuously exposed to physical forces and the central nervous system (CNS) is no exception. Cells dynamically adapt their behavior and remodel the surrounding environment in response to forces. The importance of mechanotransduction in the CNS is illustrated by exploring its role in CNS pathology development and progression. The crosstalk between the biochemical and biophysical components of the extracellular matrix (ECM) are here described, considering the recent explosion of literature demonstrating the powerful influence of biophysical stimuli like density, rigidity and geometry of the ECM on cell behavior. This review aims at integrating mechanical properties into our understanding of the molecular basis of CNS disease. The mechanisms that mediate mechanotransduction events,

SUBMITTER: Rocha DN 

PROVIDER: S-EPMC9096357 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature