Apatinib enhances the antitumor effects of radiation in HeLa cell line mouse model of invasive cervical cancer.

ABSTRACT:

Background

There is the lack of reports on apatinib (APA) combined with radiation in the treatment of cervical cancer. The aim of our study was to investigate the anti-tumor effect of APA combined with radiation using an in vivo model of cervical cancer.

Methods

The mouse models, established using Henrietta Lacks (HeLa) cells, were randomly divided into 4 groups: the control group, radiotherapy (RT) alone group, cisplatin (DDPs) combination RT group (DDPs + RT), and APA combination RT group (APA + RT). The expressions of the vascular endothelial growth factor receptor-2 (VEGFR-2), platelet endothelial cell adhesion molecule-1 (CD31), proliferating cell nuclear antigen (Ki-67), and histone H2AX family member (γ-H2AX) were determined using immunohistochemistry (IHC), th

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9096373 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature