Analysis of influencing factors on the plasma concentration of first-line anti-tuberculosis drugs-a single-center retrospective cohort study.

ABSTRACT:

Background

The four most commonly used first-line anti-tuberculosis (TB) drugs in clinical practice are isoniazid (INH), rifampicin (RFP), ethambutol (EMB), and pyrazinamide (PZA). The plasma concentration of anti-TB drugs is an important factor influencing the effectiveness of TB treatment. Factors affecting blood concentration of antituberculosis drugs have not been elaborated clearly. The purpose of this study is to investigate the status of plasma concentration of anti-TB drugs, explore the factors influencing anti-TB drug plasma concentration, and guide the rational use of clinical drugs.

Methods

This is a single-center retrospective cohort study. Patients with pulmonary TB received first-line anti-TB drugs in the 309th Hospital of the PLA from June 2014 to September 20

SUBMITTER: Zhao G 

PROVIDER: S-EPMC9096376 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature