Identification of immune-related diagnostic markers in primary Sjogren's syndrome based on bioinformatics analysis.

ABSTRACT:

Background

Primary Sjögren's syndrome (pSS) is a relatively common diffuse connective tissue disease that often invades exocrine glands, such as the lacrimal and salivary glands, and manifests as dry eyes and dry mouth. At present, the molecular mechanism of pSS is not clear. This study was designed to explore the internal mechanism of pSS from the gene level and screen out the immune-related diagnostic markers of pSS.

Methods

The gene expression profiles GSE84844, GSE7451, and GSE40611 were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified with R software. Then, the DEGs were intersected with the immune genes obtained from the ImmPort database to acquire differentially expressed immune-related genes (DEIRGs

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC9096389 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature