Effect of treatment modality on the long-term survival of patients with early glottic squamous cancer: a retrospective cohort study based on the SEER database.

ABSTRACT:

Background

The optimal treatment strategy for patients with early glottic (T1-2N0M0) squamous cancer remains unclear.

Methods

A retrospective population-based analysis was performed using the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance treatment arms, and Cox regression analysis was used to determine prognostic factors for survival. Kaplan-Meier analysis, log-rank tests, and competing risk analysis were used to compare survival outcomes between treatment modalities (surgery vs. radiotherapy).

Results

Among the 3,994 eligible patients in this study, surgery was associated with improved cancer-specific survival (CSS) and overall survival (OS) compared with radiotherapy (log-rank test, P<0.05). T

SUBMITTER: Wang WL 

PROVIDER: S-EPMC9096410 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature