Metabonomic analysis of cerebrospinal fluid in epilepsy.

ABSTRACT:

Background

We sought to explore the relationship between epilepsy and cerebrospinal fluid metabolomics and identify biomarkers for the diagnosis, treatment, and prognosis of epilepsy.

Methods

In total, 23 epileptic patients treated at The First Affiliated Hospital of Dalian Medical University from April 2019 to September 2019 were selected for the disease group and 13 non-epileptic patients were selected for the control group. Cerebrospinal fluid samples were collected from both groups, and the metabolites were analyzed by gas chromatography-mass spectrometry. The metabolites differentially expressed in the cerebrospinal fluid samples were identified. A differential metabolite enrichment analysis was performed to determine the metabolic pathways.

Results

Using a varia

SUBMITTER: Niu D 

PROVIDER: S-EPMC9096421 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature