Prognostic role of immune microenvironment in pleural metastases from breast and lung adenocarcinomas.

ABSTRACT:

Background

Pleural metastatic disease is a common disease with dismal prognosis. The immune microenvironment of metastatic pleural tissue remains largely unknown. Thus, we aimed to investigate the presence of different immune cell populations, and to compare them with clinical characteristics.

Methods

We included 70 patients with lung and breast adenocarcinoma (ADC) diagnosed with pleural metastasis during a 2-year period with the primary endpoint to investigate if the main immune cell populations are present in pleural metastases and if they have any prognostic role. Secondary endpoints were to detect any differences in their presence between lung and breast primaries and to search for any correlation with the macroscopic (thoracoscopic) findings. We used immunohistochemica

SUBMITTER: Karpathiou G 

PROVIDER: S-EPMC9096424 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature