Methodological study of directed differentiation of pluripotent stem cells into corneal endothelial cells.

ABSTRACT:

Background

Corneal transplantation is the most effective clinical treatment for irreversible corneal endothelial decompensation. However, while visual rehabilitation can be achieved by corneal transplantation, transplant rejection, poor postoperative visual acuity, and lack of suitable donor tissue are currently the greatest obstacles to corneal transplantation. As a result, endothelial cell-based therapy has emerged as an alternative to corneal transplantation treatment. Human induced pluripotent stem cells (hiPSCs) were induced to differentiate into human corneal endothelial cell (hCEC)-like cells in our study, which aimed to provide an experimental basis for studying the clinical translation and application of induced PSC (iPSC) to corneal endothelial cell (CEC) differentiation.

SUBMITTER: Jia L 

PROVIDER: S-EPMC9096426 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature