Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality.

ABSTRACT:

Background

Adjuvant and neoadjuvant breast cancer treatments can reduce breast cancer mortality but may increase mortality from other causes. Information regarding treatment benefits and risks is scattered widely through the literature. To inform clinical practice we collated and reviewed the highest quality evidence.

Methods

Guidelines were searched to identify adjuvant or neoadjuvant treatment options recommended in early invasive breast cancer. For each option, systematic literature searches identified the highest-ranking evidence. For radiotherapy risks, searches for dose-response relationships and modern organ doses were also undertaken.

Results

Treatment options recommended in the USA and elsewhere included chemotherapy (anthracycline, taxane, platinum, capecita

SUBMITTER: Kerr AJ 

PROVIDER: S-EPMC9096622 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature