Local Mucosal CO₂ but Not O₂ Insufflation Improves Gastric and Oral Microcirculatory Oxygenation in a Canine Model of Mild Hemorrhagic Shock.

ABSTRACT:

Introduction

Acute hemorrhage results in perfusion deficit and regional hypoxia. Since failure of intestinal integrity seem to be the linking element between hemorrhage, delayed multi organ failure, and mortality, it is crucial to maintain intestinal microcirculation in acute hemorrhage. During critical bleeding physicians increase FiO₂ to raise total blood oxygen content. Likewise, a systemic hypercapnia was reported to maintain microvascular oxygenation (μHbO₂). Both, O₂ and CO₂, may have adverse effects when applied systemically that might be prevented by local application. Therefore, we investigated the effects of local hyperoxia and hypercapnia on the gastric and oral microcirculation.

Methods

Six female foxhounds were anaesth

SUBMITTER: Hof S 

PROVIDER: S-EPMC9096873 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature