Opioid exposure during pregnancy and the risk of congenital malformation: a meta-analysis of cohort studies.

ABSTRACT:

Background

Opioid exposure during pregnancy has increased alarmingly in recent decades. However, the association between prenatal opioid exposure and congenital malformation risk has still been controversial. We aim to assess the association between opioid exposure during pregnancy and the risk of congenital malformations.

Method

PubMed, Embase, and Cochrane library of clinical trials were systematically searched to September 13th, 2021. Cohort studies reporting risk of congenital malformation after opioid exposure compared with non-exposure during pregnancy were included. Risk of studies was appraised with the ROBINS-I tool. Meta-analysis was conducted using the random-effects model. Subgroup analyses were conducted for the primary outcome based on indication, exposed perio

SUBMITTER: Wang X 

PROVIDER: S-EPMC9097072 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature