Trial design for ineffectiveness research: a mixed-methods survey.

ABSTRACT: High-quality research demonstrating a lack of effectiveness may facilitate the 'de-adoption' of ineffective health services. However, there has been little debate on the optimal design for ineffectiveness research-studies exploring the research hypothesis that an intervention is ineffective. The aim of this study was to explore investigators' preferences for trial design for ineffectiveness research. We conducted a mixed-methods online survey with principle investigators identified from clinicaltrials.gov. A vignette described researchers planning a trial to test a widely used intervention they hypothesised was ineffective. One multiple-choice question asked whether a superiority trial or equivalence trial design was favoured, and one free-response question asked about the reasons for that

SUBMITTER: Riggs K 

PROVIDER: S-EPMC9097110 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature