Tumor microenvironment-responsive BSA nanocarriers for combined chemo/chemodynamic cancer therapy.

ABSTRACT: Tumor microenvironment (TME), characterized by high glutathione (GSH), high hydrogen peroxide (H₂O₂) and acidic pH levels, is favorable for the growth, invasion and metastasis of cancer cells. Taking advantage of the specific characteristics of tumors, TME-responsive GCBD NPs are designed to deliver nanoscale coordination polymers (NCPs, GA-Cu) and chemotherapy drugs (doxorubicin, DOX) based on bovine serum albumin (BSA) nanocarriers into cancer cells for combined chemodynamic therapy (CDT) and chemotherapy. In an acidic environment, GCBD NPs could release approximately 90% copper ions, which can not only consume overexpressed GSH to modulate the TME but can also react with endogenous H₂O₂ in a Fenton-like reaction to achieve the CDT effect. Mean

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9097166 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature