Ontology highlight
ABSTRACT:
SUBMITTER: Cevik UA
PROVIDER: S-EPMC9097188 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Çevik Ulviye Acar UA Celik Ismail I Mella Jaime J Mellado Marco M Özkay Yusuf Y Kaplancıklı Zafer Asım ZA
ACS omega 20220428 18
In this study, a series of novel 1,3,4-oxadiazole-benzimidazole derivatives were designed and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF-7, C6, HepG2, and HeLa, were evaluated by the MTT assay. The compounds <b>5b</b>,<b>c</b> showed satisfactory potencies with much higher anticancer activity in comparison to the reference drug doxorubicin against the studied cancer cell lines. <i>In vitro</i>, enzymatic inhibition assays of aromatase (ARO) enzyme ...[more]