The genomic basis of high-elevation adaptation in wild house mice (Mus musculus domesticus) from South America.

ABSTRACT: Understanding the genetic basis of environmental adaptation in natural populations is a central goal in evolutionary biology. The conditions at high elevation, particularly the low oxygen available in the ambient air, impose a significant and chronic environmental challenge to metabolically active animals with lowland ancestry. To understand the process of adaptation to these novel conditions and to assess the repeatability of evolution over short timescales, we examined the signature of selection from complete exome sequences of house mice (Mus musculus domesticus) sampled across two elevational transects in the Andes of South America. Using phylogenetic analysis, we show that house mice colonized high elevations independently in Ecuador and Bolivia. Overall, we found distinct responses t

SUBMITTER: Beckman EJ 

PROVIDER: S-EPMC9097263 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature