Advancing Peripheral Nerve Graft Transplantation for Incomplete Spinal Cord Injury Repair.

ABSTRACT: Peripheral nerves have a propensity for axon growth and regeneration that the central nervous system lacks (CNS). However, CNS axons can also grow long distances if introduced to a graft harvested from a peripheral nerve (PNGs), which is the rationale for using PNGs as repair strategy for injuries of the spinal cord. From a clinical perspective, PNGs provide interesting possibilities with potential to repair the injured spinal cord. First, there are numerous options to harvest autologous grafts associated with low risk for the patient. Second, a PNG allow axons to grow considerable distances and can, by the surgical procedure, be navigated to specific target sites in the CNS. Furthermore, a PNG provides all necessary biological substrates for myelination of elongating axons. A PNG can thus

SUBMITTER: Kjell J 

PROVIDER: S-EPMC9097274 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature