Monocyte count and soluble markers of monocyte activation in people living with HIV and uninfected controls.

ABSTRACT:

Background

Monocytes play an important role in inflammation, and monocytosis and monocyte activation are features of chronic inflammation. We aimed to investigate if HIV status was associated with monocyte count and monocyte activation and to assess the relationship between monocyte count and monocyte activation markers and HIV-related factors.

Methods

Persons living with HIV (PLWH) with measured monocyte count and sCD14 and sCD163 were included from the Copenhagen Comorbidity in HIV infection (COCOMO) study and matched 1:5 on sex and age with uninfected controls. In addition, 74 uninfected individuals from COCOMO with measured sCD14 and sCD163 were included. Identical protocols and equipment were used to determine monocyte counts and monocyte activation in PLWH and uninfect

SUBMITTER: Knudsen AD 

PROVIDER: S-EPMC9097376 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature