Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust.

ABSTRACT:

Background

There has been growing concern regarding the impact of air pollution, especially fine dust, on human health. However, it is difficult to estimate the toxicity of fine dust on the human body because of its diverse effects depending on the composition and environmental factors.

Results

In this study, we focused on the difference in the biodistribution of fine dust according to the size distribution of particulate matter after inhalation into the body to predict its impact on human health. We synthesized Cy7-doped silica particulate matters (CSPMs) having different particle sizes and employed them as model fine dust, and studied their whole-body in vivo biodistribution in BALB/c nude mice. Image-tracking and quantitative and qualitative analyses were performed on the

SUBMITTER: Son T 

PROVIDER: S-EPMC9097390 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature