METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer.
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ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC9097454 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer.
Wang Nuofan N Huo Xinying X Zhang Baoguo B Chen Xiaoxiang X Zhao Shuli S Shi Xuesong X Xu Hao H Wei Xiaowei X
Frontiers in oncology 20220428
The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC. Functionally, we verified that METTL3 promoted tumor cell proliferation and angiogenesis through a series of phenotypic experiments. Subsequently, ADAMTS9 was identified as the downstream effector of METTL3 in GC, which could be degraded by the YTHDF2-dependent pathway. Finally, the d ...[more]
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