Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects.

ABSTRACT:

Objective

Theracurmin is a submicron dispersed formulation of curcumin, which was developed to increase the bioavailability of curcumin. This study aimed to compare the pharmacokinetics of curcumin administered as two Theracurmin powder products and unformulated curcumin powder.

Materials and methods

This randomized, three-treatment, six-sequence, and three-period crossover study enrolled 24 healthy subjects. Blood sampling was done until 12 hours after the administration of Theracurmin and curcumin powder to assess pharmacokinetics using a non-compartmental method. The plasma concentration of curcumin was determined using high-performance liquid chromatography coupled with tandem mass spectrometry.

Results

The median time to reach the maximum concentration was 1.5 - 

SUBMITTER: Chung H 

PROVIDER: S-EPMC9097512 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature