Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.

ABSTRACT:

Objective

Classical ATP-independent non-shivering thermogenesis enabled by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in the cold. It has long been suspected that futile ATP-consuming substrate cycles also contribute to thermogenesis and can partially compensate for the genetic ablation of UCP1 in mouse models. Futile ATP-dependent thermogenesis could thereby enable survival in the cold even when brown fat is less abundant or missing.

Methods

In this study, we explore different potential sources of UCP1-independent thermogenesis and identify a futile ATP-consuming triglyceride/fatty acid cycle as the main contributor to cellular heat production in brown adipocytes lacking UCP1. We uncover the mechanism on a molecul

SUBMITTER: Oeckl J 

PROVIDER: S-EPMC9097615 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature