Unifying Virulence Evaluation in Toxoplasma gondii: A Timely Task.

ABSTRACT: Toxoplasma gondii, a major zoonotic pathogen, possess a significant genetic and phenotypic diversity that have been proposed to be responsible for the variation in clinical outcomes, mainly related to reproductive failure and ocular and neurological signs. Different T. gondii haplogroups showed strong phenotypic differences in laboratory mouse infections, which provide a suitable model for mimicking acute and chronic infections. In addition, it has been observed that degrees of virulence might be related to the physiological status of the host and its genetic background. Currently, mortality rate (lethality) in outbred laboratory mice is the most significant phenotypic marker, which has been well defined for the three archetypal clonal types (I, II and III) of T. gondii

SUBMITTER: Calero-Bernal R 

PROVIDER: S-EPMC9097680 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature