Biocompatible tellurium nanoneedles with long-term stable antibacterial activity for accelerated wound healing.

ABSTRACT: Tellurium (Te) nanomaterials (NMs) have emerged as a new antibacterial candidate to respond to the complex global health challenge of bacterial resistance. Herein, Te nanoneedles (NNs) that act both chemically and physically on bacteria are synthesized by a facile method using Na₂TeO₃, urea and glucose. It is found that the prepared Te NNs have a strong affinity to the cell membrane of bacteria and subsequently promote the generation of reactive oxygen species (ROS) in bacteria, resulting in an excellent antibacterial effect toward Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). What's more, this needle-like morphology also can physically damage the bacterial cell membranes. The Te NNs per se are inert in mammalian cells to pr

SUBMITTER: Huang L 

PROVIDER: S-EPMC9097717 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature