Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis.

ABSTRACT:

Objectives

Hemophagocytic lymphohistiocytosis poses significant challenges due to limited tools to guide clinical decisions in a population at high risk of death. We sought to assess whether disseminated intravascular coagulation and hepatobiliary dysfunction, significant comorbidities seen in critical care settings, would identify hemophagocytic lymphohistiocytosis patients with increased risk of mortality.

Design

Retrospective chart review.

Setting

Single-center PICU.

Patients

All patients admitted to a tertiary care children's hospital diagnosed with hemophagocytic lymphohistiocytosis from 2005 to 2012.

Interventions

None.

Measurements and main results

Forty-three patients were diagnosed with hemophagocytic lymphohistiocytosis with median age o

SUBMITTER: Goldman J 

PROVIDER: S-EPMC9097722 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature