Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.

ABSTRACT: The formation of connections within the mammalian neocortex is highly regulated by both extracellular guidance mechanisms and intrinsic gene expression programs. There are two types of cortical projection neurons (CPNs): those that project locally and interhemispherically and those that project to subcerebral structures such as the thalamus, hindbrain, and spinal cord. The regulation of cortical projection morphologies is not yet fully understood at the molecular level. Here, we report a role for Mllt11 (Myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11/All1 Fused Gene From Chromosome 1q) in the migration and neurite outgrowth of callosal projection neurons during mouse brain formation. We show that Mllt11 expression is exclusive to developing neurons and is

SUBMITTER: Stanton-Turcotte D 

PROVIDER: S-EPMC9097781 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature