Preexisting Trichinella spiralis infection attenuates the severity of Pseudomonas aeruginosa-induced pneumonia.

ABSTRACT:

Background

A range of helminth species involve the migration of developing larvae through the lung and establish chronic infections in the host that include potent immune regulatory effects. Trichinella spiralis is one of the most successful parasitic symbiotes. After released by intestinal female adult worms, newborn larvae of T. spiralis travel through the circulatory system to the lung and finally reach skeletal muscle cells. As unique inflammation modulator of intracellular parasitism, T. spiralis shows improved responses to autoimmune disease and viral pulmonary inflammation by exerting immunomodulatory effects on innate and adaptive immune cells.

Methodology/principal findings

C57BL/6 mice were divided into four groups: uninfected; helminth- T. spiralis infected; P. ae

SUBMITTER: Long SR 

PROVIDER: S-EPMC9098000 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature