Helminth infection modulates number and function of adipose tissue Tregs in high fat diet-induced obesity.

ABSTRACT:

Background

Epidemiological and experimental studies have shown a protective effect of helminth infections in weight gain and against the development of metabolic dysfunctions in the host. However, the mechanisms Treg cells exert in the helminth-obesity interface has been poorly investigated. The present study aimed to verify the influence of Heligmosomoides polygyrus infection in early stages of high fat diet-induced obesity.

Principal findings

The presence of infection was able to prevent exacerbated weight gain in mice fed with high fat diet when compared to non-infected controls. In addition, infected animals displayed improved insulin sensitivity and decreased fat accumulation in the liver. Obesity-associated inflammation was reduced in the presence of infection, demonst

SUBMITTER: Queiroz-Glauss CP 

PROVIDER: S-EPMC9098094 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature