Solvent Drives Switching between Λ and Δ Metal Center Stereochemistry of M₈L₆ Cubic Cages.

ABSTRACT: An enantiopure ligand with four bidentate metal-binding sites and four (S)-carbon stereocenters self-assembles with octahedral Zn^II or Co^II to produce O-symmetric M₈L₆ coordination cages. The Λ- or Δ-handedness of the metal centers forming the corners of these cages is determined by the solvent environment: the same (S)-ligand produces one diastereomer, (S)₂₄-Λ₈-M₈L₆, in acetonitrile but another with opposite metal-center handedness, (S)₂₄-Δ₈-M₈L₆, in nitromethane. Van 't Hoff analysis revealed the Δ stereochemical configuration to be entropically favored but enthalpically disfavored, consistent with a loosening of the coordi

SUBMITTER: Xue W 

PROVIDER: S-EPMC9098163 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature