Design, Development, and Analysis of an Automated Sampling Loop for Online Monitoring of Chiral Crystallization.

ABSTRACT: Enantiomeric purity is of prime importance for several industries, specifically in the production of pharmaceuticals. Crystallization processes can be used to obtain pure enantiomers in a suitable solid form. However, some process variants inherently rely on kinetic enhancement (preferential crystallization) of the desired enantiomer or on complex interactions of several phenomena (e.g., attrition-enhanced deracemization and Viedma ripening). Thus, a process analytical technology able to measure the enantiomeric composition of both the solid phase and the liquid phase would be valuable to track and eventually control such processes. This study presents the design and development of a novel automated analytical monitoring system that achieves this. The designed setup tracks the enantiomeric

SUBMITTER: Rehman GU 

PROVIDER: S-EPMC9098190 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature