Activation of STING by targeting a pocket in the transmembrane domain.

ABSTRACT: Stimulator of interferon genes (STING) is an adaptor protein in innate immunity against DNA viruses or bacteria^1-5. STING-mediated immunity could be exploited in the development of vaccines or cancer immunotherapies. STING is a transmembrane dimeric protein that is located in the endoplasmic reticulum or in the Golgi apparatus. STING is activated by the binding of its cytoplasmic ligand-binding domain to cyclic dinucleotides that are produced by the DNA sensor cyclic GMP-AMP (cGAMP) synthase or by invading bacteria^1,6,7. Cyclic dinucleotides induce a conformational change in the STING ligand-binding domain, which leads to a high-order oligomerization of STING that is essential for triggering the downstream signalling pathways^8,9. However, the cGAMP-induced

SUBMITTER: Lu D 

PROVIDER: S-EPMC9098198 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature