Exploration of the Molecular Mechanisms of Hyssopus cuspidatus Boriss Treatment of Asthma in an mRNA-miRNA Network via Bioinformatics Analysis.

ABSTRACT: Hyssopus cuspidatus Boriss (H. cuspidatus) is a traditional Chinese medicine commonly used in the treatment of asthma. In the present study, we applied bioinformatics techniques for mRNA-miRNA profiling to elucidate the potential mechanisms of H. cuspidatus in asthma treatment. Bioactive compounds from H. cuspidatus, potential therapeutic targets of H. cuspidatus, and asthma-related targets were identified from the literature and databases. The intersection of H. cuspidatus-related targets and asthma-related targets was identified using the STRING platform. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using the Metascape platform. Networks were constructed from these nodes using Cytoscape. The

SUBMITTER: Cai Z 

PROVIDER: S-EPMC9098316 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature