Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis.

ABSTRACT:

Background

Pyroptosis has been shown to be involved in the overall process of atherosclerosis. This study was aimed at investigating pyroptosis-related gene expression patterns in atherosclerosis and their diagnostic significance.

Methods and results

In GSE100927, fifty-four pyroptosis-related genes were identified. Between atherosclerotic plaques and normal samples, the expression patterns of pyroptosis-related genes were significantly different. In order to construct a pyroptosis-related risk score signature (PRSS), the least absolute shrinkage and selection operator (LASSO) was combined with multivariate logistic regression to screen twelve genes. The diagnostic efficiency of the PRSS performed well in GSE43292, as shown by the results of receiver-operating characteristic

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9098329 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature