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The impact of pitolisant, an H₃ receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels.

ABSTRACT: Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H₃ receptor (H₃R) antagonists/inverse agonists enhance its release in most brain regions, including the cerebral cortex, which improves learning and memory and exerts an antiepileptic effect. However, the mechanism underlying the effect of H₃R antagonists/inverse agonists on cortical neuronal activity in vivo remains unclear. Here, we show the mechanism by which pitolisant, an H₃R antagonist/inverse agonist, influenced perirhinal cortex (PRh) activity in individual neuron and neuronal population levels. We monitored neuronal activity in the PRh of freely moving mice using in vivo Ca²⁺ imaging through a miniaturized one-phot

SUBMITTER: Hirano K

PROVIDER: S-EPMC9098477 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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The impact of pitolisant, an H₃ receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The impact of pitolisant, an H₃ receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels.