Child saliva microbiota and caries: a randomized controlled maternal education trial in rural Uganda.

ABSTRACT: Undernutrition is a public health challenge in sub-Saharan countries, including Uganda. In a previous randomized controlled trial (RCT) with a nutrition, hygiene and stimulation education intervention among mothers of 6 months' old children, we found less caries in the intervention group when the children were 36 months of age. We now examined the effects of (i) the intervention on the microbiota, (ii) microbiota on caries, and (iii) the intervention and microbiota on caries. The original RCT comprised 511 mother/child pairs whereas in the current study we had access to data from 344/511 (67%) children aged 36 months. The saliva microbiota was determined using 16S rRNA gene sequencing. Carious lesions (a proxy for dental health) were identified using close-up intra-oral photographs of the

SUBMITTER: Muhoozi GKM 

PROVIDER: S-EPMC9098507 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature