Arginase 1 is a marker of protection against illness in contacts of leprosy patients.

ABSTRACT: Leprosy household contacts are generally more prone to develop the disease compared to the general population. Previous studies have demonstrated that genes related to the alternative activation (M2) profile in macrophages are associated with the increased bacillary load in multibacillary leprosy patients (MB), and that contacts of MB patients have a higher risk of contracting the disease. In addition, positive serological responses to PGL-1 or LID-1 are associated with a higher risk of disease. We performed a 5-year follow-up of contacts of leprosy patients and evaluated the pattern of gene and protein expression in cells from contacts that developed leprosy during this period. Leprosy household contacts had decreased soluble CD163 and heme oxygenase 1 (HO-1) serum levels when compared wi

SUBMITTER: da Silva Prata RB 

PROVIDER: S-EPMC9098644 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature