Five-year outcomes of premature infants randomized to high or standard loading dose caffeine.

ABSTRACT:

Objective

To examine 5-year outcomes in children enrolled in a pilot randomized controlled trial of a high loading dose of caffeine after preterm birth.

Study design

Seventy-four very low birth weight neonates were randomized within the first 24 h of life to receive a high (80 mg/kg) or standard (20 mg/kg) loading dose of caffeine citrate. At 5 years of age, we conducted standardized neurodevelopmental tests and collected parent reports of child socioemotional problems.

Result

Seventy-four percent of survivors returned for follow up. Children obtained similar scores on neurodevelopmental and socioemotional evaluations. There was no difference in the incidence of any neurodevelopmental delay after controlling for confounding factors.

Conclusion

Five-year follow

SUBMITTER: McPherson C 

PROVIDER: S-EPMC9098661 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature