Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell-Mediated T Cell Activation.

ABSTRACT:

Background

Type 1 angiotensin (AT₁) receptors are expressed on immune cells, and we previously found that bone marrow-derived AT₁ receptors protect against Ang (angiotensin) II-induced hypertension. CD11c is expressed on myeloid cells derived from the bone marrow, including dendritic cells (DCs) that activate T lymphocytes. Here, we examined the role of AT₁ receptors on CD11c⁺ cells in hypertension pathogenesis.

Methods

Mice lacking the dominant murine AT₁ receptor isoform, AT_1a, on CD11c⁺ cells (dendritic cell [DC] AT1aR knockout [KO]) and wild-type (WT) littermates were subjected to Ang II-induced hypertension. Blood pressures were measured by radiotelemetry.

Results

DC AT1aR KO mice had ex

SUBMITTER: Lu X 

PROVIDER: S-EPMC9098690 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature