The gut microbiome of extremely preterm infants randomized to the early progression of enteral feeding.

ABSTRACT:

Background

Early progression of feeding could influence the development of the gut microbiome.

Methods

We collected fecal samples from extremely preterm infants randomized to receive either early (feeding day 2) or delayed (feeding day 5) feeding progression. After study completion, we compared samples obtained at three different time points (week 1, week 2, and week 3) to determine longitudinal differences in specific taxa between the study groups using unadjusted and adjusted negative binomial and zero-inflated mixed models. Analyses were adjusted for a mode of delivery, breastmilk intake, and exposure to antibiotics.

Results

We analyzed 137 fecal samples from 51 infants. In unadjusted and adjusted analyses, we did not observe an early transition to higher microbial

SUBMITTER: Salas AA 

PROVIDER: S-EPMC9098696 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature