ACTN3 genotype influences masseter muscle characteristics and self-reported bruxism.

ABSTRACT:

Objectives

Main aim of the study was to explore the association between genetic polymorphisms in ACTN3 and bruxism. Secondary objectives included masseter muscle phenotypes assessment between bruxers and non-bruxers and according to genetic polymorphisms in ACTN3.

Materials and methods

Fifty-four patients undergoing orthognathic surgery for correction of their malocclusion were enrolled. Self-reported bruxism and temporomandibular disorders status were preoperatively recorded. Saliva samples were used for ACTN3 genotyping. Masseter muscle samples were collected bilaterally at the time of orthognathic surgery to explore the muscle fiber characteristics.

Results

There were significant differences in genotypes for rs1815739 (R577X nonsense) (p = 0.001), rs1671064 (Q523R

SUBMITTER: Nicot R 

PROVIDER: S-EPMC9098697 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature