Dynamic planning of a two-dose vaccination campaign with uncertain supplies.

ABSTRACT: The ongoing COVID-19 pandemic has led public health authorities to face the unprecedented challenge of planning a global vaccination campaign, which for most protocols entails the administration of two doses, separated by a bounded but flexible time interval. The partial immunity already offered by the first dose and the high levels of uncertainty in the vaccine supplies have been characteristic of most of the vaccination campaigns implemented worldwide and made the planning of such interventions extremely complex. Motivated by this compelling challenge, we propose a stochastic optimization framework for optimally scheduling a two-dose vaccination campaign in the presence of uncertain supplies, taking into account constraints on the interval between the two doses and on the capacity of the

SUBMITTER: Calafiore GC 

PROVIDER: S-EPMC9098718 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature