Lasmiditan for Patients with Migraine and Contraindications to Triptans: A Post Hoc Analysis.

ABSTRACT:

Introduction

As 5-HT_1B receptor agonists, triptans produce vasoconstriction and have cardiovascular contraindications and precautions. Lasmiditan, a selective 5-HT_1F receptor agonist, has a low affinity for 5-HT_1B receptors, does not cause vasoconstriction, and is free of cardiovascular contraindications and precautions. The objective of this post hoc analysis was to evaluate the efficacy and safety of lasmiditan in patients with and without at least one triptan contraindication.

Methods

Patient subgroups, with and without triptan contraindications, were analyzed from pooled patient data from four randomized, double-blind, placebo-controlled clinical trials (SAMURAI, SPARTAN, CENTURION, and MONONOFU). Patients experiencing a single migraine a

SUBMITTER: Krege JH 

PROVIDER: S-EPMC9098729 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature