Impact of cerebral blood flow and amyloid load on SUVR bias.

ABSTRACT:

Background

Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in cerebral blood flow (CBF) and is likely to be also dependent on the extent of the underlying amyloid-β (Aβ) burden. This study aimed to compare SUVR with DVR and to evaluate the effects of underlying Aβ burden and CBF on bias in SUVR in mainly cognitively unimpaired participants. Participants were scanned according to a dual-time window protocol, with either [¹⁸F]flutemetamol (N = 90) or [¹⁸F]florbetaben (N = 31). The validated basisfunction-based implementation of the two-step simplified reference tissue model was used to derive DVR and R₁

SUBMITTER: Heeman F 

PROVIDER: S-EPMC9098761 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature