M6A Regulator-Mediated Tumour Infiltration and Methylation Modification in Cervical Cancer Microenvironment.

ABSTRACT:

Background

N6-methyladenosine (m6A) is the most abundant internal mRNA modification in eukaryotic cells. There is accumulating evidence that m6A methylation can play a significant role in the early diagnosis and treatment of cancers. However, the mechanism underlying the involvement of m6A in cervical cancer remains unclear.

Methods

Here, we examined the m6A modification patterns of immune cells in the tumour microenvironments (TMEs) of 306 patients with cervical cancer from The Cancer Genome Atlas dataset and analysed the relations between them according to 32 m6A regulators. Immune infiltration in the TME of cervical cancer was analysed using the CIBERSORT algorithm and single-sample gene set enrichment analysis. The m6Ascore was structured though principal component analy

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9098799 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature