Identification and Validation of Autophagy-Related Genes in Diabetic Retinopathy.

ABSTRACT:

Background

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes, which is associated with damage of blood-retinal barrier and ischemia of retinal vasculature. It devastates visual acuity due to leakage of retinal vessels and aberrant pathological angiogenesis in diabetic patients. The etiology of DR is complex, accumulated studies have shown that autophagy plays an important role in the pathogenesis of DR, but its specific mechanism needs to be further studied.

Methods

This study chose the online Gene Expression Omnibus (GEO) microarray expression profiling dataset GSE146615 to carry on the research. Autophagy-related genes that were potentially differentially expressed in DR were screened by R software. Then, the differentially express

SUBMITTER: Wang N 

PROVIDER: S-EPMC9098829 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature