Tim-3⁺ decidual Mφs induced Th2 and Treg bias in decidual CD4⁺T cells and promoted pregnancy maintenance via CD132.

ABSTRACT: T-cell immunoglobulin mucin-3 (Tim-3) plays roles in the functional regulation of both adaptive and innate immune cells and is greatly involved in many diseases. However, the precise roles of Tim-3 on macrophages (Mφs) in pregnancy remain unstated. In the current study, we found the higher frequency of Tim-3⁺ decidual Mφs (dMφs) in response to trophoblasts. The reduced abundance of Tim-3 on Mφs was accompanied by disordered anti- and pro-inflammatory cytokine profiles in miscarriage. Adoptive transfer of Tim-3⁺Mφs, but not Tim-3^-Mφs, relieved murine embryo absorption induced by Mφ depletion. Our flow cytometry results and the extensive microarray analysis confirmed that Tim-3⁺ and Tim-3^-dMφs were neither precisely pro-inflammatory (M1)

SUBMITTER: Li M 

PROVIDER: S-EPMC9098864 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature