Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic-ischemic encephalopathy.

ABSTRACT: Brain injury at birth is an important cause of neurological and behavioral disorders. Hypoxic-ischemic encephalopathy (HIE) is a critical cerebral event occurring acutely or chronically at birth with high mortality and morbidity in newborns. Therapeutic strategies for the prevention of brain damage are still unknown, and the only medical intervention for newborns with moderate-to-severe HIE is therapeutic hypothermia (TH). Although the neurological outcome depends on the severity of the initial insult, emerging evidence suggests that infants with mild HIE who are not treated with TH have an increased risk for neurodevelopmental impairment; in the current clinical setting, there are no specific or validated biomarkers that can be used to both correlate the severity of the hypoxic insult at

SUBMITTER: Tarocco A 

PROVIDER: S-EPMC9098891 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature